Protein Crystallography and
Biophysics Centre (BiophysX)
Institute of Structural and Molecular Biology
(ISMB)
Birkbeck College / University College London
Mid- and
Far-Infrared
Spectroscopy
(Bruker Vertex 80v and
IFS/66s)
Vibrational
infrared (IR) spectroscopy
covers the 4000 to 200 cm-1
(2500 to 50000 nm) spectral
range. It is complementary to,
and is generally more
informative than,
UV/visible/near-IR electronic
spectra as almost all
molecules have characteristic
IR spectra. Typical projects
include measuring protein and
cofactor changes in different
intermediates or quantifying
specific biochemicals in
clinical samples for
diagnostics.
These machines can be operated
in transmission or ‘ATR’ mode
and have DTGS, MCT and helium
bolometer detectors. We also
have technology to combine IR
measurements with
electrochemistry,
photochemistry and cyclic
addition/removal of ligands.
Potential
users should firstly contactusto
discuss project feasibility
and sample requirements,
together with likely machine
requirements and access
charges.