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Protein Crystallography and
Biophysics Centre (BiophysX)
Institute of Structural and Molecular Biology (ISMB) School of Natural Sciences Birkbeck College / University College London |
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About Us The Protein Crystallography and Biophysics Center (BiophysX) at ISMB provides access to instrumentation and expertise for structural biology experiments covering protein crystallography and several biophysical methods to members of ISMB, at Birkbeck and UCL groups as well as to other research groups located in London. Updates A new RT-PCR instrument (CFX Duet / Biorad) is now available at the Center. A new VARIOSKAN LUX plate reader has been installed in the lab. More information about applications and possibilities please follow the link on the right. Refer to Birkbeck web pages or contact us regarding updated charges for Master's and PhD students. Protein Crystallography BiophysX provides access to equipment and supplies for crystallization experiments including initial screenings, crystal monitoring and optimization. Equipment includes: LCP mosquito (STP Labtech) with humidity control Hydra II 96-channel liquid handler Formulator (Formulatrix), crystallisation screen builder. UVEXps256 (Swissci) imaging system with polariser and UV for monitoring of crystal growth The Laboratory is is running rolling BAG applications for access Diamond Light Source and ESRF covering research groups from Birkbeck, UCL, QMUL and Kingston University. Biophysics A variety of instrumentation is available for the characterization of equilibrium and kinetic behaviors of protein, nucleic acid and small-molecule interactions on a hire, service or collaborative basis. For an overview of the methods and techniques available, please click here. Planning an experiment Please read the overview for basic information and contact the Centre Manager for an information sheet and questionnaire on a specific technique. More detailed planning will depend on the information you return to us. Usual pitfalls are the solubility or stability of your sample at the buffer conditions required and the lack of suitable controls. Thorough data analysis is essential before conclusions are drawn from any biophysical experiment. Please discuss this in advance as well. Please also note that our safety regulations (Health and safety/Emergency links) need to be followed in any case.. Access Currently most of the biophysics equipment of the previously known as Biophysics Centre has been moved in room B16 were is is merged with the existing Protein Crystallography Laboratory. The new space offers a wider range of equipment under the same space as also it is easier accessible for the external users. Please contact the Centre Manager if you have any queries. Bookings for biophysics equipment can be made and viewed here. If you have no valid login, please book through the Centre Manager. Charges depend on the instrument and on the amount of training required and service to be provided. We charge to cover cost and only if there is sufficient funding on your project. Please enquire. For future projects involving BiophysX please contact us well in advance of your grant application. Contact and Location Protein Crystallography and Biophysics Centre, Institute of Molecular and Structural Biology, School of Natural Sciences, B16 Birkbeck, University of London Malet Street London, WC1E 7HX Tel +44 (0)20 3926 3507 Email crystallogaphy (at ) bbk ac uk Click here for maps of the college and surroundings. Please note some instrumentation is located nearby at UCL.
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