Protein Crystallography and Biophysics Centre (BiophysX)
Institute of Structural and Molecular Biology (ISMB)
Birkbeck College / University College London

The Protein Crystallography Laboratory offers a full suite of facilities and support enabling each user to study the structure of macromolecules, including challenging projects on membrane proteins, DNA/RNA complexes etc by means mainly of X-ray crystallography. We provide the facilities, equipment and advice to guide each user through the whole process from optimising the sample, crystallising and getting the structure, up to interpreting the structural model.

An SPT Labtech Mosquito LCP is available for setting vapour diffusion experiments, supported by a formulator (Formulatrix) liquid handler as well as additional robotics equipment for setting up easily, reliably and fast crystallisation experiments.

The two temperature controlled crystallisation rooms at 20oC and 4oC are equipped with crystal growth monitoring hotels (UVEX PS-256 and an old Rigaku respectively) with the possibility for remote inspections through a web browser. Additional incubators for setting up experiments at different temperatures are available.

The crystallography lab is organising Beam Allocation Group (BAG) proposals with groups from Birkbeck/UCL and other Institutes in London. We have access at the Diamond Light Source, ESRF Grenoble and EMBL-Hamburg Petra III for protein crystallography and SAXS beamlines.

The Laboratory provides in addition assistance for the computational work. Crystallography software has been installed in our Linux Clusters at the Institute offering fast data processing.

ISMB Protein Crystallography and Biophysics Centre, Birkbeck, University of London
Last modified April 2021